hCAIX-IN-10

Modify Date: 2024-01-22 15:05:22

hCAIX-IN-10 Structure
hCAIX-IN-10 structure
Common Name hCAIX-IN-10
CAS Number 2497504-72-8 Molecular Weight 479.55
Density N/A Boiling Point N/A
Molecular Formula C28H21N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of hCAIX-IN-10


hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].

 Names

Name hCAIX-IN-10

 hCAIX-IN-10 Biological Activity

Description hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].
Related Catalog
Target

Ki: 61.5 nM (hCA IX), 586.8 nM (hCA XII)[1]

In Vitro hCAIX-IN-10 (compound 6i) is a strong inhibitor of hCA IX rather than hCA XII in vitro[1]. hCAIX-IN-10 (0.1 nM-0.1 mM; 6 h) inhibits carbonic anhydrases enzyme activity[1].
References

[1]. Pavitra S Thacker,et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.

 Chemical & Physical Properties

Molecular Formula C28H21N3O3S
Molecular Weight 479.55