2497504-72-8

2497504-72-8 structure

Name: hCAIX-IN-10
Chemical Name: hCAIX-IN-10
CAS Number: 2497504-72-8
Molecular Formula: C₂₈H₂₁N₃O₃S
Molecular Weight: 479.55
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-08-03 15:08:06
Modify Date: 2024-01-22 15:05:22
hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].

Name	hCAIX-IN-10

Description	hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Target	Ki: 61.5 nM (hCA IX), 586.8 nM (hCA XII)[1]
In Vitro	hCAIX-IN-10 (compound 6i) is a strong inhibitor of hCA IX rather than hCA XII in vitro[1]. hCAIX-IN-10 (0.1 nM-0.1 mM; 6 h) inhibits carbonic anhydrases enzyme activity[1].
References	[1]. Pavitra S Thacker,et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.

Molecular Formula	C₂₈H₂₁N₃O₃S
Molecular Weight	479.55