alpha-Hederin

Modify Date: 2024-01-02 12:18:53

alpha-Hederin structure	Common Name	alpha-Hederin
	CAS Number	27013-91-8	Molecular Weight	750.956
	Density	1.3±0.1 g/cm3	Boiling Point	849.6±65.0 °C at 760 mmHg
	Molecular Formula	C₄₁H₆₆O₁₂	Melting Point	215ºC (dec.)
	MSDS	Chinese USA	Flash Point	250.7±27.8 °C

Use of alpha-Hederin

alpha-hederin is a water-soluble pentacyclic triterpenoid saponin, possessing several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation，In vitro: a-hederin is cytotoxic and inhibits proliferation in bothcel lines at rather low concentrations. , a-hederin reduces themitotic activity in treated cels.[1]In vivo: alpha-hederin had preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses. [2]

Name	kalopanaxsaponin A
Synonym	More Synonyms

Description	alpha-hederin is a water-soluble pentacyclic triterpenoid saponin, possessing several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation，In vitro: a-hederin is cytotoxic and inhibits proliferation in bothcel lines at rather low concentrations. , a-hederin reduces themitotic activity in treated cels.[1]In vivo: alpha-hederin had preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses. [2]
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Others
References	[1]. Danloy S et al. Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Med, 1994 Feb, 60(1):45-9. [2]. Maryam Fallahi et al. Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats. Planta Med, 1994 Feb, 60(1):45-9.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Natural Products >> Terpenoids and Glycosides

Research Areas >> Others

References

[1]. Danloy S et al. Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Med, 1994 Feb, 60(1):45-9.

[2]. Maryam Fallahi et al. Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats. Planta Med, 1994 Feb, 60(1):45-9.

Density	1.3±0.1 g/cm3
Boiling Point	849.6±65.0 °C at 760 mmHg
Melting Point	215ºC (dec.)
Molecular Formula	C₄₁H₆₆O₁₂
Molecular Weight	750.956
Flash Point	250.7±27.8 °C
Exact Mass	750.455444
PSA	195.60000
LogP	8.37
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.601
Storage condition	2~8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RK0177800

CHEMICAL NAME :: Olean-12-en-28-oic acid, 3-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arab inopyranosyl) oxy)-23-hydroxy-, (3-beta,4-alpha)-

CAS REGISTRY NUMBER :: 27013-91-8

BEILSTEIN REFERENCE NO. :: 0076156

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C41-H66-O12

MOLECULAR WEIGHT :: 751.07

WISWESSER LINE NOTATION :: L F6 E6 B666 CUTJ F1 J1Q J1 N1 O1 RVQ U1 U1 IO- BT6OTJ DQ EQ CO- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,545,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,545,1980

Hazard Codes	Xi
Risk Phrases	22
Safety Phrases	22-45-24/25
RIDADR	UN 1544
RTECS	RK0177800

Precursor 8
CAS#:14216-03-6 Hederacoside C CAS#:84607-60-3 hederagenin 3-O... CAS#:29321-28-6 hederagenin 3-O... CAS#:87733-79-7 Mukurozi-saponin E1
CAS#:87781-65-5 mukurozisaponin Y1 CAS#:33289-85-9 Dipsacoside B CAS#:87733-77-5 mukurozi-saponin X CAS#:120481-41-6 3-O-[α-L-rhamno...
DownStream 4
CAS#:465-99-6 Hederagenin CAS#:17184-21-3 Cauloside A CAS#:73-34-7 6-methyloxane-2... CAS#:87-72-9 L-Arabinopyranose

Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin.

J. Biol. Chem. 288(20) , 14000-17, (2013)

The interactions of triterpenoid monodesmosidic saponins, α-hederin and δ-hederin, with lipid membranes are involved in their permeabilizing effect. Unfortunately, the interactions of these saponins w...

Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.

Biochemistry 48(15) , 3477-82, (2009)

Hederacoside C, alpha-hederin, and hederagenin are saponins of dry extracts obtained from the leaves of ivy (Hedera helix L.). Internalization of beta(2)-adrenergic receptor-GFP fusion proteins after ...

Participation of cholinergic pathways in α-hederin-induced contraction of rat isolated stomach strips.

Phytomedicine 19(7) , 591-5, (2012)

The dry extract of Hedra helix leaves and its main active compounds, predominantly α-hederin and hederacoside C, has been traditionally believed to act spasmolytic. However, it has been recently prove...

α-Hederin

(3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxyolean-12-en-28-oic acid

Alpha-hederin

glycosidel-e1

Olean-12-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)-

UNII:4H15F0GLV2

sapindosidea

HELIXIN

nepalin2

dipsacobioside

Hederoside B

koronaroside A

hederosidec

akebosidestc

taurosidee

A-HEDERIN

SAPINDOSIDE A

HEDERIN

Hederin, α-

alpha-Hederin

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China
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Henan Tianfu Chemical Co., Ltd.
China
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alpha-Hederin

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