Thalidomide-PEG5-NH2 hydrochloride

Modify Date: 2024-01-12 11:49:08

Thalidomide-PEG5-NH2 hydrochloride structure	Common Name	Thalidomide-PEG5-NH2 hydrochloride
	CAS Number	2703775-06-6	Molecular Weight	529.97
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₂ClN₃O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-PEG5-NH2 hydrochloride

Thalidomide-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name	Thalidomide-PEG5-NH2 hydrochloride

Description	Thalidomide-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTAC 包含两个不同的配体，通过一个接头连接；一个是 E3 泛素连接酶的配体，另一个是靶蛋白的配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[2]。
References	[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1005.

Molecular Formula	C₂₃H₃₂ClN₃O₉
Molecular Weight	529.97