Gedunin
Modify Date: 2024-01-04 14:26:23
Gedunin structure
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Common Name | Gedunin | ||
|---|---|---|---|---|
| CAS Number | 2753-30-2 | Molecular Weight | 482.56500 | |
| Density | 1.28g/cm3 | Boiling Point | 594.3ºC at 760mmHg | |
| Molecular Formula | C28H34O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 313.2ºC | |
Use of GeduninGedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research[3]. |
| Name | gedunin |
|---|---|
| Synonym | More Synonyms |
| Description | Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research[3]. |
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| Related Catalog | |
| Target |
HSP90 |
| In Vitro | Gedunin (0.5-30 μM) inhibits CaCo-2 colon cancer cell proliferationin a dose-dependent manner, and the IC50 value is 16.83 µM[1]. |
| References |
| Density | 1.28g/cm3 |
|---|---|
| Boiling Point | 594.3ºC at 760mmHg |
| Molecular Formula | C28H34O7 |
| Molecular Weight | 482.56500 |
| Flash Point | 313.2ºC |
| Exact Mass | 482.23000 |
| PSA | 95.34000 |
| LogP | 4.56070 |
| Vapour Pressure | 4.31E-14mmHg at 25°C |
| Index of Refraction | 1.581 |
|
~74%
Gedunin CAS#:2753-30-2 |
| Literature: Haldar, Saikat; Kolet, Swati P.; Thulasiram, Hirekodathakallu V. Green Chemistry, 2013 , vol. 15, # 5 p. 1311 - 1317 |
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~%
Gedunin CAS#:2753-30-2 |
| Literature: Saxena, Meera; Srivastava, Santosh K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1087 - 1088 |
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~%
Gedunin CAS#:2753-30-2 |
| Literature: Saxena, Meera; Srivastava, Santosh K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1087 - 1088 |
| Precursor 3 | |
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| DownStream 0 | |
| Gedunin,(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione |
| Gedunine |