2753-30-2

2753-30-2 structure

Name: Gedunin
Chemical Name: gedunin
CAS Number: 2753-30-2
Molecular Formula: C₂₈H₃₄O₇
Molecular Weight: 482.56500
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2018-06-18 16:00:23
Modify Date: 2024-01-04 14:26:23
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research[3].

Name	gedunin
Synonyms	Gedunin,(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione Gedunine

Description	Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90
In Vitro	Gedunin (0.5-30 μM) inhibits CaCo-2 colon cancer cell proliferationin a dose-dependent manner, and the IC50 value is 16.83 µM[1].
References	[1]. Shaikh J Uddin, et al. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother Res. 2007 Aug;21(8):757-61. [2]. Gary E L Brandt, et al. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J Med Chem. 2008 Oct 23;51(20):6495-502 [3]. Seshu Vardhan, et al. Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells. J Tradit Complement Med. 2021 Apr 12.

Density	1.28g/cm3
Boiling Point	594.3ºC at 760mmHg
Molecular Formula	C₂₈H₃₄O₇
Molecular Weight	482.56500
Flash Point	313.2ºC
Exact Mass	482.23000
PSA	95.34000
LogP	4.56070
Vapour Pressure	4.31E-14mmHg at 25°C
Index of Refraction	1.581

58525-91-0

~74%

2753-30-2

Literature: Haldar, Saikat; Kolet, Swati P.; Thulasiram, Hirekodathakallu V. Green Chemistry, 2013 , vol. 15, # 5 p. 1311 - 1317

106984-18-3

2753-30-2

Literature: Saxena, Meera; Srivastava, Santosh K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1087 - 1088

106984-19-4

2753-30-2

Literature: Saxena, Meera; Srivastava, Santosh K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1087 - 1088

Precursor 3
58525-91-0 106984-18-3 106984-19-4
DownStream 0

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