HIV-1 inhibitor-15

Modify Date: 2024-01-12 22:01:12

HIV-1 inhibitor-15 structure	Common Name	HIV-1 inhibitor-15
	CAS Number	2757182-99-1	Molecular Weight	392.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₀N₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIV-1 inhibitor-15

HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].

Name	HIV-1 inhibitor-15

Description	HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 (WT):1.7 nM (EC50) HIV-1 (L100I):4 nM (EC50) HIV-1 (K103N):2 nM (EC50) HIV-1 (Y181C):6 nM (EC50) HIV-1 (E138K):9 nM (EC50)
References	[1]. Ding L, et al. Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK. J Med Chem. 2022;65(3):2122-2138.

Molecular Formula	C₂₄H₂₀N₆
Molecular Weight	392.46

HIV-1 inhibitor-15

Use of HIV-1 inhibitor-15

Names

HIV-1 inhibitor-15 Biological Activity

Chemical & Physical Properties