DB0614

Modify Date: 2024-08-20 18:30:51

DB0614 Structure
DB0614 structure
Common Name DB0614
CAS Number 2769753-47-9 Molecular Weight 822.95
Density N/A Boiling Point N/A
Molecular Formula C41H42N8O7S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DB0614


DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

 Names

Name DB0614

 DB0614 Biological Activity

Description DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1].
Related Catalog
Target

CDK6

CDK16/Cyclin Y

ULK1

Aurora Kinase

SIK2

LIMK2

References

[1]. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.

 Chemical & Physical Properties

Molecular Formula C41H42N8O7S2
Molecular Weight 822.95