DB1113

Modify Date: 2024-01-17 10:45:52

DB1113 structure	Common Name	DB1113
	CAS Number	2769753-53-7	Molecular Weight	1144.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₉H₆₈F₃N₁₃O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DB1113

DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

Name	DB1113

Description	DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP4K Signaling Pathways >> MAPK/ERK Pathway >> MAPKAPK2 (MK2) Research Areas >> Others Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Autophagy >> ULK Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK) Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)
Target	CDK4 CDK11B MAP4K2 SIK2 SIK3 MAP4K5 HPK1 GLK/MAP4K3 ULK1 LIMK1
References	[1]. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.

Molecular Formula	C₅₉H₆₈F₃N₁₃O₆S
Molecular Weight	1144.31

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DB1113
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Purity: 99.0%
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DB1113

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DB1113 Biological Activity

Chemical & Physical Properties