4-Ethynyl-L-phenylalanine
Modify Date: 2024-01-10 22:27:33
4-Ethynyl-L-phenylalanine structure
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Common Name | 4-Ethynyl-L-phenylalanine | ||
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| CAS Number | 278605-15-5 | Molecular Weight | 189.210 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 343.2±37.0 °C at 760 mmHg | |
| Molecular Formula | C11H11NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 161.4±26.5 °C | |
Use of 4-Ethynyl-L-phenylalanine4-Ethynyl-L-phenylalanine is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1]. |
| Name | (2S)-2-amino-3-(4-ethynylphenyl)propanoic acid |
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| Synonym | More Synonyms |
| Description | 4-Ethynyl-L-phenylalanine is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1]. |
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| Related Catalog | |
| Target |
Ki: 32.6 μM (TPH)[1] |
| In Vivo | 4-Ethynyl-L-phenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1]. 4-Ethynyl-L-phenylalanine is not inhibiting the aromatic amino acid decarboxylase[1]. 4-Ethynyl-L-phenylalanine has a low affinity for various recombinant 5-HT receptors[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1] Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 343.2±37.0 °C at 760 mmHg |
| Molecular Formula | C11H11NO2 |
| Molecular Weight | 189.210 |
| Flash Point | 161.4±26.5 °C |
| Exact Mass | 189.078979 |
| PSA | 63.32000 |
| LogP | 1.29 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Hazard Codes | Xi |
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| L-Phenylalanine,4-ethynyl |
| p-ethynylphenylalanine |
| Phenylalanine, 4-ethynyl- |
| 4-Ethynyl-L-phenylalanine HCl |
| 4-Ethynylphenylalanine |