Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt

Modify Date: 2024-01-09 17:04:18

Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt Structure
Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt structure
Common Name Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt
CAS Number 292633-16-0 Molecular Weight 711.719
Density 1.4±0.1 g/cm3 Boiling Point 1258.1±65.0 °C at 760 mmHg
Molecular Formula C33H41N7O11 Melting Point N/A
MSDS N/A Flash Point 714.6±34.3 °C

 Use of Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt


Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity[1].

 Names

Name ac-leu-glu-his-asp-amc
Synonym More Synonyms

  Biological Activity

Description Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity[1].
Related Catalog
References

[1]. Igor M Prudnikov, et al. Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases. J Biochem. 2012 Mar;151(3):299-316.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1258.1±65.0 °C at 760 mmHg
Molecular Formula C33H41N7O11
Molecular Weight 711.719
Flash Point 714.6±34.3 °C
Exact Mass 711.286377
PSA 278.99000
LogP 0.94
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.605

 Synonyms

N-Acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine
ac-lehd-amc trifluoroacetate salt
L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
ac-lehd-amc
ac-lehd-mca
n-acetyl-leu-glu-his-asp-7-amino-4-methylcoumarin amc
ac-leu-glu-his-asp-mca
ac-leu-glu-his-asp-7-amino-4-methylcoumarin
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