Desmethylbellidifolin

Modify Date: 2024-01-08 09:28:21

Desmethylbellidifolin Structure
Desmethylbellidifolin structure
Common Name Desmethylbellidifolin
CAS Number 2980-32-7 Molecular Weight 260.199
Density 1.8±0.1 g/cm3 Boiling Point 605.6±55.0 °C at 760 mmHg
Molecular Formula C13H8O6 Melting Point 317ºC
MSDS N/A Flash Point 242.0±25.0 °C

 Use of Desmethylbellidifolin


1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity[1].

 Names

Name bellidin
Synonym More Synonyms

 Desmethylbellidifolin Biological Activity

Description 1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity[1].
Related Catalog
In Vitro 1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) attenuates lipopolysaccharide-induced nitric oxide release and proinflammatory cytokine expression in RAW264.7 cells[1].
In Vivo 1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin; orally; 5, 10, 20 mg/kg; 12 days) can inhibit trinitrobenzenesulfonic acid (TNBS)-induced ulcerative colitis (UC), reducing inflammatory response and alleviate colon muscle spasm[1].
References

[1]. Ni Y, et al. Desmethylbellidifolin From Gentianella acuta Ameliorate TNBS-Induced Ulcerative Colitis Through Antispasmodic Effect and Anti-Inflammation. Front Pharmacol. 2019 Sep 20;10:1104. 

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 605.6±55.0 °C at 760 mmHg
Melting Point 317ºC
Molecular Formula C13H8O6
Molecular Weight 260.199
Flash Point 242.0±25.0 °C
Exact Mass 260.032074
PSA 111.13000
LogP 0.33
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.801

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZD6122300
CHEMICAL NAME :
Xanthen-9-one, 1,3,5,8-tetrahydroxy-
CAS REGISTRY NUMBER :
2980-32-7
BEILSTEIN REFERENCE NO. :
0286545
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H8-O6
MOLECULAR WEIGHT :
260.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
20 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 150,141,1985

 Synthetic Route

 Synonyms

Demethylbellidifolin
Xanthen-9-one,1,3,5,8-tetrahydroxy
Desmethylbellidifolin
Bellidin
norbellidifolin
1,3,5,8-tetrahydroxyxanthone
Desmethybellidifolin
norbellidifodin
1,3,5,8-Tetrahydroxy-9H-xanthen-9-one
9H-Xanthen-9-one, 1,3,5,8-tetrahydroxy-
1,3,5,8-tetrahydroxy-xanthen-9-one
1,3,5,8-tetrahydroxyxanthen-9-one