Sorbitol dehydrogenase-IN-1

Modify Date: 2024-04-06 11:52:33

Sorbitol dehydrogenase-IN-1 structure	Common Name	Sorbitol dehydrogenase-IN-1
	CAS Number	300551-49-9	Molecular Weight	343.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₅N₇O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Sorbitol dehydrogenase-IN-1

Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively[1].

Name	Sorbitol dehydrogenase-IN-1

Description	Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	Sorbitol Dehydrogenase[1]
In Vivo	Sorbitol dehydrogenase-IN-1 (compound 16) (50 µg/kg；口服) 在慢性糖尿病大鼠中表现出对坐骨神经果糖的持续抑制作用[1]。
References	[1]. Mylari BL, et al. A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem. 2002 Sep 26;45(20):4398-401.

Molecular Formula	C₁₇H₂₅N₇O
Molecular Weight	343.43