Corydalmine

Modify Date: 2024-01-07 13:05:51

Corydalmine Structure
Corydalmine structure
Common Name Corydalmine
CAS Number 30413-84-4 Molecular Weight 341.401
Density 1.3±0.1 g/cm3 Boiling Point 501.2±50.0 °C at 760 mmHg
Molecular Formula C20H23NO4 Melting Point 177-178℃
MSDS N/A Flash Point 256.9±30.1 °C

 Use of Corydalmine


Corydalmine (L-Corydalmine), an alkaloid isolated from roots of Corydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].

 Names

Name (13aS)-2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2 -a]isoquinolin-10-ol
Synonym More Synonyms

 Corydalmine Biological Activity

Description Corydalmine (L-Corydalmine), an alkaloid isolated from roots of Corydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].
Related Catalog
Target

CXCR2

In Vivo Corydalmine (L-Corydalmine) is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes[2].
References

[1]. S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From Corydalis Chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71.

[2]. Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105.

[3]. Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 501.2±50.0 °C at 760 mmHg
Melting Point 177-178℃
Molecular Formula C20H23NO4
Molecular Weight 341.401
Flash Point 256.9±30.1 °C
Exact Mass 341.162720
PSA 51.16000
LogP 2.93
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.640

 Safety Information

Hazard Codes Xi

 Synonyms

6H-Dibenzo[a,g]quinolizin-10-ol, 5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (13aS)-
6H-Dibenzo(a,g)quinolizin-10-ol, 5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (S)-
(13aS)-2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-10-ol
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