TCS JNK 5a

Modify Date: 2024-01-03 14:21:14

TCS JNK 5a Structure
TCS JNK 5a structure
Common Name TCS JNK 5a
CAS Number 312917-14-9 Molecular Weight 332.419
Density 1.3±0.1 g/cm3 Boiling Point 486.8±45.0 °C at 760 mmHg
Molecular Formula C20H16N2OS Melting Point N/A
MSDS N/A Flash Point 248.2±28.7 °C

 Use of TCS JNK 5a


TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.

 Names

Name N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
Synonym More Synonyms

 TCS JNK 5a Biological Activity

Description TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.
Related Catalog
Target

JNK3:6.7 (pIC50)

JNK2:6.5 (pIC50)

In Vitro TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them[1].
References

[1]. Angell RM, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 486.8±45.0 °C at 760 mmHg
Molecular Formula C20H16N2OS
Molecular Weight 332.419
Flash Point 248.2±28.7 °C
Exact Mass 332.098328
PSA 81.13000
LogP 5.46
Appearance of Characters light yellow solid
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.699
Storage condition Store at RT

 Safety Information

 Synonyms

F0016-0404
1-Naphthalenecarboxamide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
JNK Inhibitor IX
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthamide
TCS JNK 5a
SC-20267
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
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