894804-07-0

894804-07-0 structure

Name: TCS JNK 6o
Chemical Name: N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
CAS Number: 894804-07-0
Molecular Formula: C₁₈H₂₀N₄O₄
Molecular Weight: 356.38
Catalog: Signaling Pathways MAPK/ERK Pathway JNK
Create Date: 2017-10-10 13:21:11
Modify Date: 2024-01-13 21:49:43
JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with ki values of 2 nM, 4 nM, 52 nM, respectively[1].

Name	N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
Synonyms	IN1283 benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy- aminopyridine deriv. 2 HMS3229K06 JNK Inhibitor VIII Kinome_3020 N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2-(2,5-dimethoxyphenyl)acetamide

Description	JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with ki values of 2 nM, 4 nM, 52 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> JNK
Target	JNK1:2 nM (Ki) JNK2:4 nM (Ki) JNK3:52 nM (Ki)
In Vitro	JNK Inhibitor VIII (TCS JNK 6o) shows over 1000- fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38α, and p38δ[1].
References	[1]. Szczepankiewicz BG, et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.