317353-73-4

317353-73-4 structure

Name: TCS 2314
Chemical Name: [1-({(3S)-4-[(4-{[(2-Methylphenyl)carbamoyl]amino}phenyl)acetyl]- 3-morpholinyl}carbonyl)-4-piperidinyl]acetic acid
CAS Number: 317353-73-4
Molecular Formula: C₂₈H₃₄N₄O₆
Molecular Weight: 522.59
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-02-10 03:55:20
Modify Date: 2024-01-12 19:33:23
TCS 2314 is a very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM[1].

Name	[1-({(3S)-4-[(4-{[(2-Methylphenyl)carbamoyl]amino}phenyl)acetyl]- 3-morpholinyl}carbonyl)-4-piperidinyl]acetic acid
Synonyms	BX 513 hydrochloride

Description	TCS 2314 is a very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 4.4 nM (Very late antigen-4)[1]
References	[1]. Muro F, et al. Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J Med Chem. 2009 Dec 24;52(24):7974-92.