ICA 110381

Modify Date: 2024-01-03 18:08:26

ICA 110381 structure	Common Name	ICA 110381
	CAS Number	325457-99-6	Molecular Weight	267.11
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₈Cl₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ICA 110381

ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].

Name	4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Synonym	More Synonyms

Description	ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1] IC50: 15 μM (KCNQ1)[1]
References	[1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

Molecular Formula	C₁₂H₈Cl₂N₂O
Molecular Weight	267.11
Exact Mass	266.00100
PSA	41.99000
LogP	3.71370

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ICA 110381 Structure

ICA 110381

CAS#:325457-99-6

Literature: Amato, George; Roeloffs, Rosemarie; Rigdon, Greg C.; Antonio, Brett; Mersch, Theresa; McNaughton-Smith, Grant; Wickenden, Alan D.; Fritch, Paul; Suto, Mark J. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 6 p. 481 - 484

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ICA 110381 Structure

ICA 110381

CAS#:325457-99-6

Literature: Amato, George; Roeloffs, Rosemarie; Rigdon, Greg C.; Antonio, Brett; Mersch, Theresa; McNaughton-Smith, Grant; Wickenden, Alan D.; Fritch, Paul; Suto, Mark J. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 6 p. 481 - 484

4-Chlorobenzoic acid structure

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ICA 110381 Structure

ICA 110381

CAS#:325457-99-6

Literature: Amato, George; Roeloffs, Rosemarie; Rigdon, Greg C.; Antonio, Brett; Mersch, Theresa; McNaughton-Smith, Grant; Wickenden, Alan D.; Fritch, Paul; Suto, Mark J. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 6 p. 481 - 484

2-acetamido-6-chloropyridine

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ICA 110381
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ICA 110381 (Compound 16)
Price: $550.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: ICA 110381 (Compound 16)
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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