HIF-1 inhibitor-4

Modify Date: 2024-04-05 18:15:55

HIF-1 inhibitor-4 Structure
HIF-1 inhibitor-4 structure
Common Name HIF-1 inhibitor-4
CAS Number 333357-56-5 Molecular Weight 422.26013
Density N/A Boiling Point N/A
Molecular Formula C18H19IN2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIF-1 inhibitor-4


HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].

 Names

Name WAY-299838
Synonym More Synonyms

 HIF-1 inhibitor-4 Biological Activity

Description HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].
Related Catalog
In Vitro HIF-1 inhibitor-4 (Compound 1) 抑制 HIF-1,IC50 为 560 nM (使用 U251 细胞进行定量,在 VEGF 启动子 (VEGF-PLAP) 的控制下表达 PLAP 报告基因)[1]。
References

[1]. Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29.  

 Chemical & Physical Properties

Molecular Formula C18H19IN2O2
Molecular Weight 422.26013

 Synonyms

Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)-
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