8-Nitro-D-guanosine

Modify Date: 2024-08-12 21:02:08

8-Nitro-D-guanosine Structure
8-Nitro-D-guanosine structure
Common Name 8-Nitro-D-guanosine
CAS Number 337536-53-5 Molecular Weight 328.24
Density N/A Boiling Point N/A
Molecular Formula C10H12N6O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 8-Nitro-D-guanosine


8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

 Names

Name 8-Nitroguanosine
Synonym More Synonyms

 8-Nitro-D-guanosine Biological Activity

Description 8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog
References

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

 Chemical & Physical Properties

Molecular Formula C10H12N6O7
Molecular Weight 328.24
Exact Mass 328.07700
PSA 205.33000

 Synonyms

2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-nitro-3H-purin-6-one
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