JX-401

Modify Date: 2024-01-02 14:01:05

JX-401 Structure
JX-401 structure
Common Name JX-401
CAS Number 349087-34-9 Molecular Weight 355.49400
Density 1.17g/cm3 Boiling Point 537.3ºC at 760 mmHg
Molecular Formula C21H25NO2S Melting Point N/A
MSDS N/A Flash Point 278.8ºC

 Use of JX-401


JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].

 Names

Name (4-benzylpiperidin-1-yl)-(2-methoxy-4-methylsulfanylphenyl)methanone
Synonym More Synonyms

 JX-401 Biological Activity

Description JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].
Related Catalog
References

[1]. Friedmann Y, et al. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol. 2006;70(4):1395-1405.

 Chemical & Physical Properties

Density 1.17g/cm3
Boiling Point 537.3ºC at 760 mmHg
Molecular Formula C21H25NO2S
Molecular Weight 355.49400
Flash Point 278.8ºC
Exact Mass 355.16100
PSA 54.84000
LogP 4.44990
Index of Refraction 1.611

 Safety Information

Risk Phrases R50/53
Safety Phrases 60-61
RIDADR UN 3077 9/PG 3

 Synonyms

1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine
JX401