Neurotensin
Modify Date: 2024-01-13 10:55:22
Neurotensin structure
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Common Name | Neurotensin | ||
|---|---|---|---|---|
| CAS Number | 39379-15-2 | Molecular Weight | 1672.92000 | |
| Density | 1.46g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C78H121N21O20 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NeurotensinNeurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR). |
| Name | neurotensin |
|---|---|
| Synonym | More Synonyms |
| Description | Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR). |
|---|---|
| Related Catalog | |
| Target |
Neurotensin receptors (NTR)[1] |
| In Vitro | Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca2+]i), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin[1]. |
| References |
| Density | 1.46g/cm3 |
|---|---|
| Molecular Formula | C78H121N21O20 |
| Molecular Weight | 1672.92000 |
| Exact Mass | 1671.91000 |
| PSA | 668.69000 |
| LogP | 4.50630 |
| Index of Refraction | 1.666 |
| Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RTECS | QQ4482000 |
|---|
| NEUROTENSIN,BOVINE |
| GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU |
| M.W. 1672.92 C78H121N21O20 |
| PGLU-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU |
| PYR-LYENKPRRPYIL |
| Neurotensin |
| PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Neurotensin
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
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- Email: sales@echemcloud.com
- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Pyr-LYENKPRRPyIL
- Price: $Inquiry/1kg
- Purity: 98.0%
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- Email: ymbetter@glbiochem.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: NEUROTENSIN
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: Neurotensin
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Delivery: 1 Day
- Contact: Vinnie
- Email: Jamie@api-made.com
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Price: $60/1mg
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