ST-148

Modify Date: 2024-01-19 18:22:06

ST-148 Structure
ST-148 structure
Common Name ST-148
CAS Number 400863-77-6 Molecular Weight 421.537
Density N/A Boiling Point N/A
Molecular Formula C21H19N5OS2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ST-148


ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein; exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively; significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice.

 Names

Name ST-148

 ST-148 Biological Activity

Description ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein; exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively; significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice.
References References 1. Byrd CM, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):15-25. 2. Scaturro P, et al. J Virol. 2014 Oct;88(19):11540-55. View Related Products by Target Filovirus

 Chemical & Physical Properties

Molecular Formula C21H19N5OS2
Molecular Weight 421.537