5'-O-Dimethoxytrityl-deoxythymidine

Modify Date: 2024-01-03 13:35:27

5'-O-Dimethoxytrityl-deoxythymidine Structure
5'-O-Dimethoxytrityl-deoxythymidine structure
Common Name 5'-O-Dimethoxytrityl-deoxythymidine
CAS Number 40615-39-2 Molecular Weight 528.596
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C31H32N2O7 Melting Point 114-116 °C (subl.)(lit.)
MSDS Chinese USA Flash Point N/A

 Use of 5'-O-Dimethoxytrityl-deoxythymidine


5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides[1].

 Names

Name 5'-O-(4,4'-Dimethoxytrityl)thymidine
Synonym More Synonyms

 5'-O-Dimethoxytrityl-deoxythymidine Biological Activity

Description 5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides[1].
Related Catalog
References

[1]. Lars Holmberg. Method and means for oligonucleotide synthesis. WO1992009615A1.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Melting Point 114-116 °C (subl.)(lit.)
Molecular Formula C31H32N2O7
Molecular Weight 528.596
Exact Mass 528.226013
PSA 112.01000
LogP 6.97
Index of Refraction 1.596
Storage condition −20°C
Stability Store in Freezer

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29349990

 Synthetic Route

 Customs

HS Code 29349990

 Articles6

More Articles
Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method.

Nucleic Acids Res. 8(22) , 5473-89, (1980)

Synthesis of two oligothymidylic acids, tridecamer and nonadecamer, is described by a rapid and simple solid-phase method on two kinds of polyacrylamide supports derivatized from commercially availabl...

Synthesis of mixed oligodeoxyribonucleotides following the solid phase method.

Nucleic Acids Res. 10(10) , 3291-301, (1982)

A method for the synthesis of mixed dimers, trimers and oligonucleotides on a solid support using monomeric protected nucleoside phosphochloridites (1a-d) has been developed and the different nucleosi...

Synthesis of 14 C-radiolabeled oligonucleotides with a novel phosphoramidite reagent.

Bioorg. Med. Chem. Lett. 8(9) , 1123-6, (1998)

A novel solid-phase synthesis of 5'-radiolabeled oligonucleotides is described. The labeling reaction is carried out by the phosphoramidite method with the aid of [4,6-di-14C]-5'-dimethoxytritylthymid...

 Synonyms

Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-
5'-O-dimethyltritylthymidine
5'-O-(Bis(4-methoxyphenyl)phenylmethyl)thymidine
EINECS 255-003-1
2,4(1H,3H)-pyrimidinedione, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-glycero-pentofuranosyl]-5-methyl-
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-[(2R,5S)-tetrahydro-5-[1-methoxy-1-(methyldioxy)-2,2,2-triphenylethyl]-2-furanyl]-
1-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-β-D-glycero-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione
MFCD00010113
5′-O-(4,4′-Dimethoxytrityl)thymidine
5'-O-Dimethoxytrityl-deoxythymidine
1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
DMTr-dThd
5‘-O-Dimethoxytrityl-deoxythymidine
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]thymidine
1-{(2R,5S)-5-[1-Methoxy-1-(methylperoxy)-2,2,2-triphenylethyl]tetrahydro-2-furanyl}-5-methyl-2,4(1H,3H)-pyrimidinedione
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