ZM 449829
ZM 449829 structure
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Common Name | ZM 449829 | ||
|---|---|---|---|---|
| CAS Number | 4452-06-6 | Molecular Weight | 182.218 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 319.3±15.0 °C at 760 mmHg | |
| Molecular Formula | C13H10O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 137.5±15.3 °C | |
Use of ZM 449829ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1]. |
| Name | naphthyl vinyl ketone |
|---|---|
| Synonym | More Synonyms |
| Description | ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1]. |
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| Related Catalog | |
| Target |
JAK3:6.8 (pIC50) |
| In Vitro | ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC50=5.0) , Jak1 (pIC50=4.7), and tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation[2]. Western Blot Analysis[2] Cell Line: YTS, NK92, and ex vivo NK cells Concentration: 1 μM Incubation Time: 30 minutes pretreatment Result: Inhibits the phosphorylation of STAT5. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 319.3±15.0 °C at 760 mmHg |
| Molecular Formula | C13H10O |
| Molecular Weight | 182.218 |
| Flash Point | 137.5±15.3 °C |
| Exact Mass | 182.073166 |
| PSA | 17.07000 |
| LogP | 3.11 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.619 |
| HS Code | 2914399090 |
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|
~42%
ZM 449829 CAS#:4452-06-6 |
| Literature: Hanthorn, Jason J.; Pratt, Derek A. Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 276 - 284 |
|
~42%
ZM 449829 CAS#:4452-06-6 |
| Literature: Matsuo, Jun-Ichi; Aizawa, Yayoi Chemical Communications, 2005 , # 18 p. 2399 - 2401 |
|
~73%
ZM 449829 CAS#:4452-06-6 |
| Literature: Riofski, Mark V.; John, Jinu P.; Zheng, Mary M.; Kirshner, Julia; Colby, David A. Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 3676 - 3683 |
|
~45%
ZM 449829 CAS#:4452-06-6 |
| Literature: Yang, Tang-Po; Li, Qiang; Lin, Jin-Hong; Xiao, Ji-Chang Chemical Communications, 2014 , vol. 50, # 9 p. 1077 - 1079 |
|
~%
ZM 449829 CAS#:4452-06-6 |
| Literature: Sheshenev, Andrey E.; Boltukhina, Ekaterina V.; White, Andrew J. P.; Hii, King Kuok Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6988 - 6991 Angew. Chem., 2013 , vol. 125, # 27 p. 7126 - 7129,4 |
|
~%
ZM 449829 CAS#:4452-06-6 |
| Literature: Sane,P.P. et al. Synthesis, 1973 , p. 541 - 542 |
|
~%
ZM 449829 CAS#:4452-06-6 |
| Literature: Dannenberg; Rahman Chemische Berichte, 1955 , vol. 88, p. 1405,1413 |
|
~%
ZM 449829 CAS#:4452-06-6 |
| Literature: Matsuo, Jun-Ichi; Aizawa, Yayoi Chemical Communications, 2005 , # 18 p. 2399 - 2401 |
| Precursor 10 | |
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| DownStream 1 | |
CAS#:123183-98-2| HS Code | 2914399090 |
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| Summary | 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
| 1-(2-naphthyl)prop-2-en-1-one |
| 1-b-Naphthylpiperazine |
| 2-Propen-1-one, 1-(2-naphthalenyl)- |
| 3-naphthyl piperazine |
| vinyl phenyl ketone |
| 1-(2-Naphthyl)-2-propen-1-one |