4452-06-6
4452-06-6 structure
- Name: ZM 449829
- Chemical Name: naphthyl vinyl ketone
- CAS Number: 4452-06-6
- Molecular Formula: C13H10O
- Molecular Weight: 182.218
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2018-03-15 08:00:00
- Modify Date: 2024-01-02 16:49:12
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ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1].
| Name | naphthyl vinyl ketone |
|---|---|
| Synonyms |
1-(2-naphthyl)prop-2-en-1-one
1-b-Naphthylpiperazine 2-Propen-1-one, 1-(2-naphthalenyl)- 3-naphthyl piperazine vinyl phenyl ketone 1-(2-Naphthyl)-2-propen-1-one |
| Description | ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1]. |
|---|---|
| Related Catalog | |
| Target |
JAK3:6.8 (pIC50) |
| In Vitro | ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC50=5.0) , Jak1 (pIC50=4.7), and tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation[2]. Western Blot Analysis[2] Cell Line: YTS, NK92, and ex vivo NK cells Concentration: 1 μM Incubation Time: 30 minutes pretreatment Result: Inhibits the phosphorylation of STAT5. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 319.3±15.0 °C at 760 mmHg |
| Molecular Formula | C13H10O |
| Molecular Weight | 182.218 |
| Flash Point | 137.5±15.3 °C |
| Exact Mass | 182.073166 |
| PSA | 17.07000 |
| LogP | 3.11 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.619 |
| HS Code | 2914399090 |
|---|
| Precursor 10 | |
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| DownStream 1 | |
| HS Code | 2914399090 |
|---|---|
| Summary | 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |