Betulonic acid

Modify Date: 2024-01-02 08:56:59

Betulonic acid structure	Common Name	Betulonic acid
	CAS Number	4481-62-3	Molecular Weight	454.684
	Density	1.1±0.1 g/cm3	Boiling Point	548.1±33.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₆O₃	Melting Point	264 °C
	MSDS	N/A	Flash Point	299.4±21.9 °C

Use of Betulonic acid

Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1]In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2]

Name	Betulonicacid
Synonym	More Synonyms

Description	Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1]In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Terpenoids and Glycosides
References	[1]. Zhang J et al. Employing rubusoside to improve the solubility and permeability of antitumor compound betulonic acid. Nanomedicine (Lond). 2016 Oct 19. [2]. Semenov DE et al. Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol.Bull Exp Biol Med. 2015 Jan;158(3):336-41.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Terpenoids and Glycosides

References

[1]. Zhang J et al. Employing rubusoside to improve the solubility and permeability of antitumor compound betulonic acid. Nanomedicine (Lond). 2016 Oct 19.

[2]. Semenov DE et al. Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol.Bull Exp Biol Med. 2015 Jan;158(3):336-41.

Density	1.1±0.1 g/cm3
Boiling Point	548.1±33.0 °C at 760 mmHg
Melting Point	264 °C
Molecular Formula	C₃₀H₄₆O₃
Molecular Weight	454.684
Flash Point	299.4±21.9 °C
Exact Mass	454.344696
PSA	54.37000
LogP	8.36
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.527

Hazard Codes	Xi
Safety Phrases	24/25

Precursor 8
CAS#:472-15-1 Betulinic acid CAS#:473-98-3 Betulin CAS#:13159-28-9 Betulinaldehyde CAS#:7020-34-0 3-Oxobetulin
CAS#:1721-69-3 Lup-20(29)-ene-... CAS#:1072913-62-2 (1R,3aS,5aR,5bR... CAS#:64-19-7 acetic acid CAS#:110-86-1 Pyridine
DownStream 4
CAS#:472-15-1 Betulinic acid CAS#:38736-77-5 3-epi-betulinic acid CAS#:174022-42-5 Bevirimat CAS#:150840-33-8 11-[[(1R,3aS,5a...