Betulonic acid

Modify Date: 2024-01-02 08:56:59

Betulonic acid Structure
Betulonic acid structure
Common Name Betulonic acid
CAS Number 4481-62-3 Molecular Weight 454.684
Density 1.1±0.1 g/cm3 Boiling Point 548.1±33.0 °C at 760 mmHg
Molecular Formula C30H46O3 Melting Point 264 °C
MSDS N/A Flash Point 299.4±21.9 °C

 Use of Betulonic acid


Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1]In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2]

 Names

Name Betulonicacid
Synonym More Synonyms

 Betulonic acid Biological Activity

Description Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1]In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2]
Related Catalog
References

[1]. Zhang J et al. Employing rubusoside to improve the solubility and permeability of antitumor compound betulonic acid. Nanomedicine (Lond). 2016 Oct 19.

[2]. Semenov DE et al. Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol.Bull Exp Biol Med. 2015 Jan;158(3):336-41.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 548.1±33.0 °C at 760 mmHg
Melting Point 264 °C
Molecular Formula C30H46O3
Molecular Weight 454.684
Flash Point 299.4±21.9 °C
Exact Mass 454.344696
PSA 54.37000
LogP 8.36
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.527

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25

 Synthetic Route

 Synonyms

Betulinonic acid
3-Oxolup-20(29)-en-28-oic acid
Liquidambaricacid
Betulonic acid
Lup-20(29)-en-28-oic acid, 3-oxo-
LiquidaMba
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