farnesol

Modify Date: 2024-01-03 17:27:28

farnesol structure	Common Name	farnesol
	CAS Number	4602-84-0	Molecular Weight	222.366
	Density	0.9±0.1 g/cm3	Boiling Point	283.4±0.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₆O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	96.1±0.0 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of farnesol

Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.

Name	farnesol
Synonym	More Synonyms

Description	Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Terpenoids and Glycosides
Target	Human Endogenous Metabolite
In Vitro	Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans. It is also shown that this molecule presents inhibitory effects against non-albicans Candida species, Paracoccidioides brasiliensis and bacteria. The minimum inhibitory concentrations (MICs) are determined in accordance with the M27-A3 protocol as described and Farnesol is tested at a concentration range of 0.29-150 μM. It is observed that Farnesol presents an inhibitory activity against C. neoformans and C. gattii (MIC range: 0.29-75.0 μM). Although Farnesol does not significantly alter phospholipase activity, a tendency to decrease this activity is observed[1].
References	[1]. Cordeiro Rde A, et al. Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. Vet Microbiol. 2012 Oct 12;159(3-4):375-80.

Density	0.9±0.1 g/cm3
Boiling Point	283.4±0.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₆O
Molecular Weight	222.366
Flash Point	96.1±0.0 °C
Exact Mass	222.198364
PSA	20.23000
LogP	5.31
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.485
Storage condition	−20°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.

farnesol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR4979000

CHEMICAL NAME :: 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-

CAS REGISTRY NUMBER :: 4602-84-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H26-O

MOLECULAR WEIGHT :: 222.41

WISWESSER LINE NOTATION :: Q2UY1&3UY1&3UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 443 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Insect - not otherwise specified Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 43,1285,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5190 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H315-H317-H319-H411
Precautionary Statements	P273-P280-P333 + P313-P337 + P313-P391-P501
Personal Protective Equipment	Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes	Xi: Irritant;
Risk Phrases	R24/25
Safety Phrases	S22-S24/25
RIDADR	UN 3082 9 / PGIII
WGK Germany	3
RTECS	JR4979000
HS Code	2905290000

Precursor 9
CAS#:89637-63-8 benzoic acid,3,... CAS#:19317-11-4 FARNESAL CAS#:7212-44-4 Nerolidol CAS#:10485-70-8 methyl farnesoate
CAS#:85633-25-6 farnesyl formiate CAS#:80767-67-5 alpha-bisabolyl... CAS#:79858-01-8 ethyl 3,7,11-tr... CAS#:64-19-7 acetic acid
CAS#:78-79-5 isoprene
DownStream 10
CAS#:10485-70-8 methyl farnesoate CAS#:3891-98-3 2,6,10-Trimethy... CAS#:6750-34-1 hexahydrofarnesol CAS#:505-32-8 ISOPHYTOL
CAS#:16106-95-9 2Z,6Z-Farnesol CAS#:3879-60-5 (E,Z)-3,7,11-Tr... CAS#:3790-71-4 (Z,E)-farnesol CAS#:106-28-5 (2E,6E)-Farnesol
CAS#:515-69-5 alpha-Bisabolol CAS#:64-18-6 Formic Acid

HS Code	2905290000
Summary	2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Developmentally regulated sesquiterpene production confers resistance to Colletotrichum gloeosporioides in ripe pepper fruits.

PLoS ONE 9(10) , e109453, (2014)

Sesquiterpenoid capsidiol, exhibiting antifungal activity against pathogenic fungus, is accumulated in infected ripe pepper fruits. In this study, we found a negative relation between the capsidiol le...

Farnesol induces apoptosis-like cell death in the pathogenic fungus Aspergillus flavus.

Mycologia 106(5) , 881-8, (2014)

Farnesol (FOH) is known to induce apoptosis in some fungi and mammalian cells. We treated Aspergillus flavus, one of the leading causes of human invasive aspergillosis and a key producer of the most p...

Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms.

PLoS ONE 10 , e0133886, (2015)

Streptococcus mutans is the primary causative agent of dental caries, one of the most prevalent diseases in the United States. Previously published studies have shown that Pluronic-based tooth-binding...

(2-trans,6-trans)-farnesol

(E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol

Stirrup-TPW

Stirrup-HB

(2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trien-1-ol

trans,trans-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol

(2E,6E)-Farnesol

all-trans-farnesol

all-E-Farnesol

Farnesoi

EINECS 225-004-1

MFCD00002918

farnesyl bromide

2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (E,E)-

(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol

trans,trans-Farnesol

2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2E,6E)-

3,7,10-trimethyl-2,6,10-dodecatrien-1-ol

ALL TRANS FARNESOL

FARNESOLP

trans-Farnesol

Farnesol,(E,E)

3,7,11-Trimethyl-2,6,10-dodecatrienol

(E)-farnesol

farnesyl alcohol

(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol

3,7,11-Trimethyl-2,6,10-Dodecatrien-1-ol

E,E-farnesol

Stirrup-CRW

Polyprenol

Stirrup-H

Farnesol

(E,E)-Farnesol

3,7,11-Trimethyldodeca-2,6,10-trien-1-ol

3,7,11-Trimethyldodeca-2-trans,6-trans,10-trien-1-ol

fci119a

Inhibitor A2

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: farnesol
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: farnesol
Price: ￥218.0/25g ￥78.0/5g
Purity: 96.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: HSDB 445
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: HSDB 445
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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farnesol

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