4-Phenylbutyric acid-d2

Modify Date: 2024-01-01 19:12:35

4-Phenylbutyric acid-d2 structure	Common Name	4-Phenylbutyric acid-d2
	CAS Number	461391-24-2	Molecular Weight	168.22600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₈D₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 4-Phenylbutyric acid-d2

4-Phenylbutyric acid-d2 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

Name	4-phenylbutyric-2,2,3,3-d4 acid

Description	4-Phenylbutyric acid-d2 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [3]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15242:24-29. [4]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May151:9-17.

Molecular Formula	C₁₀H₈D₄O₂
Molecular Weight	168.22600
Exact Mass	168.10900
PSA	37.30000
LogP	2.09390