Proscillaridin A structure
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Common Name | Proscillaridin A | ||
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CAS Number | 466-06-8 | Molecular Weight | 530.650 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 716.7±60.0 °C at 760 mmHg | |
Molecular Formula | C30H42O8 | Melting Point | 233ºC | |
MSDS | Chinese USA | Flash Point | 232.6±26.4 °C | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of Proscillaridin AProscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1]. |
Name | Proscillaridin A |
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Synonym | More Synonyms |
Description | Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1]. |
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Related Catalog | |
Target |
Topoisomerase I:30 nM (IC50) Topoisomerase II:100 nM (IC50) |
In Vitro | Proscillaridin A (0-160 nM; 48 hours) reveals the antiproliferative response in a time- as well as dose-dependent manner in MCF-7 cells[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 716.7±60.0 °C at 760 mmHg |
Melting Point | 233ºC |
Molecular Formula | C30H42O8 |
Molecular Weight | 530.650 |
Flash Point | 232.6±26.4 °C |
Exact Mass | 530.287964 |
PSA | 129.59000 |
LogP | 3.90 |
Vapour Pressure | 0.0±5.2 mmHg at 25°C |
Index of Refraction | 1.620 |
Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | R25 |
Safety Phrases | 28-45 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | UK6650000 |
Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound.
Hypertension 27(5) , 1073-8, (1996) Endogenous digitalis-like factors in humans are presumably cardenolides and bufadienolides. To test whether bufadienolide-like substances may circulate in human blood, we used antibodies from rabbits ... |
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Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.
J. Nat. Prod. 72 , 1969-74, (2009) Cardiac glycosides have been reported to exhibit cytotoxic activity against several different cancer types, but studies against colorectal cancer are lacking. In a screening procedure aimed at identif... |
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Role of endogenous cardiac glycosides in the spontaneously hypertensive rat--antagonism by active immunization.
Am. J. Hypertens. 9(1) , 81-5, (1996) The effects of simultaneous active immunization against two cardiac glycoside drugs, digoxin and proscillaridin, have been examined in young spontaneously hypertensive and Wistar-Kyoto rats. Control a... |
Bufa-4,20,22-trienolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-14-hydroxy-, (3β)- |
Protasin |
14-Hydroxy-3b-(rhamnosyloxy)bufa-4,20,22-trienolide |
(3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolid |
Scillarenin 3β-rhamnoside |
3-β-((6-Deoxy-α-L-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienolide |
5-[(3S,8R,9S,10R,13R,14S,17R)-14-Hydroxy-10,13-dimethyl-3-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-pyran-2-on |
Desgluco-transvaalin |
Urgilan |
Herzo proscillan |
Scillarenin 3b-Rhamnoside |
Scillarenin 3a-L-Rhamnopyranoside |
3b-Rhamnosido-14b-hydroxy-D4,20,22-bufatrienolide |
Proscillaridin |
Scillacrist |
Desglucotransvaaline |
Coratol |
Scilla "didier" |
(3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide |
Purosin-TC |
Sandoscill |
Wirnesin |
Caratol |
(3b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide |
3b-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide |
Tradenal |
Herzo |
Bufa-4,20,22-trienolide, 3-((6-deoxy-α-L-mannopyranosyl)oxy)-14-hydroxy-, (3β)- |
psc-801 |
Caradrin |
Cardion |
14-Hydroxy-3β-(rhamnosyloxy)bufa-4,20,22-trienolide |
Cardiovite |
Prostosin |
Proslladin |
Solestril |
Stellarid |
proszin |
proscillaridin-A |
Talucard |
Carmazon |
Simeon |
Procilan |
5-[(3S,8R,9S,10R,13R,14S,17R)-14-Hydroxy-10,13-dimethyl-3-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-pyran-2-one |
Talusin |
5-[(3S,8R,9S,10R,13R,14S,17R)-14-Hydroxy-10,13-diméthyl-3-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yl]-2H-pyran-2-one |
Procardin |
Caradrine |
Proscillan |