Desaminotyrosine

Modify Date: 2024-01-02 09:09:00

Desaminotyrosine structure	Common Name	Desaminotyrosine
	CAS Number	501-97-3	Molecular Weight	166.174
	Density	1.3±0.1 g/cm3	Boiling Point	352.4±17.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₀O₃	Melting Point	129-131 °C(lit.)
	MSDS	Chinese USA	Flash Point	181.1±17.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of Desaminotyrosine

Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

Name	phloretic acid
Synonym	More Synonyms

Description	Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Natural Products >> Saccharides and Glycosides
Target	Human Endogenous Metabolite
In Vivo	Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice[1].
Animal Admin	Mice[1] Indicated mice receive 200 mM Desaminotyrosine dissolved in Kool-Aid in the drinking water (control animals receive Kool-Aid alone). Indicated mice receive poly(IC) injections of 1 mg/kg for vancomycin, neomycin, ampicillin, and metronidazole (VNAM) treated mice or 5 mg/kg for all other mice intraperitoneally daily for 4 days, and then mice are scarified on day five at which time serum is collected[1].
References	[1]. Steed AL, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502.

Density	1.3±0.1 g/cm3
Boiling Point	352.4±17.0 °C at 760 mmHg
Melting Point	129-131 °C(lit.)
Molecular Formula	C₉H₁₀O₃
Molecular Weight	166.174
Flash Point	181.1±17.4 °C
Exact Mass	166.062988
PSA	57.53000
LogP	1.10
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.580
Storage condition	2-8°C
Water Solubility	slightly soluble

Desaminotyrosine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW5342000

CHEMICAL NAME :: Hydrocinnamic acid, p-hydroxy-

CAS REGISTRY NUMBER :: 501-97-3

BEILSTEIN REFERENCE NO. :: 2209841

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H10-O3

MOLECULAR WEIGHT :: 166.19

WISWESSER LINE NOTATION :: QV2R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1809 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,265,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MW5342000
HS Code	2916399090

Precursor 10
CAS#:7400-08-0 p-Hydroxy-cinna... CAS#:84253-22-5 3-(4-((2,4-dime... CAS#:1929-29-9 3-(4-Methoxyphe... CAS#:6272-45-3 3-[4-(Benzyloxy...
CAS#:123-08-0 4-hydroxybenzal... CAS#:70-70-2 1-(4-Hydroxyphe... CAS#:31770-76-0 3-(4-Hydroxyphe... CAS#:84253-18-9 3-(4-((2,4-dime...
CAS#:22767-72-2 Ethyl 3-(4-meth... CAS#:60-18-4 L-Tyrosine
DownStream 10
CAS#:37827-68-2 7-Hydroxy-2-tet... CAS#:60-82-2 Phloretin CAS#:920318-17-8 4-hydroxy-6-[2-... CAS#:31770-76-0 3-(4-Hydroxyphe...
CAS#:34675-84-8 cetraxate CAS#:34071-95-9 Benzenepropanoi... CAS#:4919-34-0 Benzenepropanoi... CAS#:51-67-2 Tyramine
CAS#:50463-48-4 3-(4-Benzyloxyp... CAS#:20238-83-9 3-(4-hydroxyphe...

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Hydroxycinnamic acids used as external acceptors of electrons: an energetic advantage for strictly heterofermentative lactic acid bacteria.

Appl. Environ. Microbiol. 80(24) , 7574-82, (2014)

The metabolism of hydroxycinnamic acids by strictly heterofermentative lactic acid bacteria (19 strains) was investigated as a potential alternative energy route. Lactobacillus curvatus PE5 was the mo...

A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.

J. Nucl. Med. 139 , 2309-14, (2009)

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio...

Development of a targeted method for twenty-three metabolites related to polyphenol gut microbial metabolism in biological samples, using SPE and UHPLC-ESI-MS/MS.

Talanta 128 , 221-30, (2014)

An increasing number of studies have concerned the profiling of polyphenol microbial metabolites, especially in urine or plasma, but only a few have regarded their accurate quantification. This study ...

Benzenepropanoic acid, 4-hydroxy-

4-hydroxy-benzenepropanoic acid

MFCD00002778

3-(p-hydroxyphenyl)propionic acid

4-Hydroxyhydrocinnamic Acid

3-(4-Hydroxyphenyl)propanoic acid

Phloretic acid

3-(p-Hydroxyphenyl)propionic acid,Phloretic acid

3-(para-Hydroxyphenyl)propionic acid

3-(4-Hydroxyphenyl)-propionic acid

3-(4-Hydroxyphenyl)propionic acid

b-(p-Hydroxyphenyl)propionic acid

p-hydroxy-hydrocinnamic acid

EINECS 207-931-3

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China
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China
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China
Product Name: 501-97-3
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