Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Desaminotyrosine
Price:
Purity: 98.0%
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BioBioPha
China
Product Name: Desaminotyrosine
Price: ￥Inquiry/5mg
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Desaminotyrosine
Price: ￥108.0/25g ￥318.0/100g ￥98.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
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DC Chemicals Limited
China
Product Name: Phloretic acid
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-(4-Hydroxyphenyl)propionic acid
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Purity: 98.0%
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501-97-3

501-97-3 structure

501-97-3 structure

Name: Desaminotyrosine
Chemical Name: phloretic acid
CAS Number: 501-97-3
Molecular Formula: C₉H₁₀O₃
Molecular Weight: 166.174
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2018-06-18 18:35:23
Modify Date: 2024-01-02 09:09:00
Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

Name	phloretic acid
Synonyms	Benzenepropanoic acid, 4-hydroxy- 4-hydroxy-benzenepropanoic acid MFCD00002778 3-(p-hydroxyphenyl)propionic acid 4-Hydroxyhydrocinnamic Acid 3-(4-Hydroxyphenyl)propanoic acid Phloretic acid 3-(p-Hydroxyphenyl)propionic acid,Phloretic acid 3-(para-Hydroxyphenyl)propionic acid 3-(4-Hydroxyphenyl)-propionic acid 3-(4-Hydroxyphenyl)propionic acid b-(p-Hydroxyphenyl)propionic acid p-hydroxy-hydrocinnamic acid EINECS 207-931-3

Description	Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Natural Products >> Saccharides and Glycosides
Target	Human Endogenous Metabolite
In Vivo	Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice[1].
Animal Admin	Mice[1] Indicated mice receive 200 mM Desaminotyrosine dissolved in Kool-Aid in the drinking water (control animals receive Kool-Aid alone). Indicated mice receive poly(IC) injections of 1 mg/kg for vancomycin, neomycin, ampicillin, and metronidazole (VNAM) treated mice or 5 mg/kg for all other mice intraperitoneally daily for 4 days, and then mice are scarified on day five at which time serum is collected[1].
References	[1]. Steed AL, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502.

Density	1.3±0.1 g/cm3
Boiling Point	352.4±17.0 °C at 760 mmHg
Melting Point	129-131 °C(lit.)
Molecular Formula	C₉H₁₀O₃
Molecular Weight	166.174
Flash Point	181.1±17.4 °C
Exact Mass	166.062988
PSA	57.53000
LogP	1.10
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.580
Storage condition	2-8°C
Water Solubility	slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW5342000

CHEMICAL NAME :: Hydrocinnamic acid, p-hydroxy-

CAS REGISTRY NUMBER :: 501-97-3

BEILSTEIN REFERENCE NO. :: 2209841

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H10-O3

MOLECULAR WEIGHT :: 166.19

WISWESSER LINE NOTATION :: QV2R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1809 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,265,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MW5342000
HS Code	2916399090

Precursor 10
7400-08-0 84253-22-5 1929-29-9 6272-45-3
123-08-0 70-70-2 31770-76-0 84253-18-9
22767-72-2 60-18-4
DownStream 10
37827-68-2 60-82-2 920318-17-8 31770-76-0
34675-84-8 34071-95-9 4919-34-0 51-67-2
50463-48-4 20238-83-9

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%