Shanghai Nianxing Industrial Co., Ltd
China
Product Name: p-Hydroxy-cinnamic acid
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: p-Hydroxy-cinnamic acid
Price: ￥198.0/20mg ￥318.0/100g ￥108.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: p-Hydroxy-cinnamic acid
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxycinnamic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-coumaric acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

7400-08-0

7400-08-0 structure

Name: p-Hydroxy-cinnamic acid
Chemical Name: 4-coumaric acid
CAS Number: 7400-08-0
Molecular Formula: C₉H₈O₃
Molecular Weight: 164.158
Catalog: Flavors and spices Synthetic spice Aromatic cinnamic acid, esters and derivatives
Create Date: 2018-06-13 18:22:17
Modify Date: 2024-01-02 18:24:45
p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.

Name	4-coumaric acid
Synonyms	p-Hydroxycinnamic acid b-[4-Hydroxyphenyl]acrylic Acid E-4-HydroxycinnamicAcid 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)- 4-Coumaric acid 4-Hydroxycinnamic acid p-Hydroxycinnamic acid, trans 2-Propenoic acid, 3- (4-hydroxyphenyl)- (2E)-3-(4-Hydroxyphenyl)acrylic acid (E)-4-Hydroxycinnamic acid EINECS 231-000-0 trans-p-hydroxycinnamic acid PARA-HYDROXYCINNAMIC ACID p-coumaric acid hydroxycinnamic acid p-Coumaric acid, trans trans-4-hydroxycinnamic acid trans-4-coumaric acid trans-p-Coumaric Acid (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid β-[4-hydroxyphenyl]acrylic acid p-Hydroxy-cinnamic acid (E)-p-hydroxycinnamic acid β-(4-Hydroxyphenyl)acrylic acid MFCD00004399

Description	p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Natural Products >> Acids and Aldehydes Research Areas >> Others
Target	PGE2:126 μM (IC50) TXB2:371 μM (IC50) Human Endogenous Metabolite
In Vitro	p-Hydroxycinnamic acid (p-Coumaric acid), is a ubiquitous plant metabolite with antioxidant and anti-inflammatory properties. p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55•2 (SE 4•01) % and 35•6 (SE 2•35) % relative to basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary haemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1].
References	[1]. Luceri C, et al. p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. Br J Nutr. 2007 Mar;97(3):458-63.

Density	1.3±0.1 g/cm3
Boiling Point	346.1±17.0 °C at 760 mmHg
Melting Point	212-214ºC
Molecular Formula	C₉H₈O₃
Molecular Weight	164.158
Flash Point	177.3±17.4 °C
Exact Mass	164.047348
PSA	57.53000
LogP	1.88
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.660
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD9094000

CHEMICAL NAME :: Cinnamic acid, p-hydroxy-

CAS REGISTRY NUMBER :: 7400-08-0

BEILSTEIN REFERENCE NO. :: 2207383

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H8-O3

MOLECULAR WEIGHT :: 164.17

WISWESSER LINE NOTATION :: QV1U1R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 657 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 104,793,1984 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2800 mg/kg

SEX/DURATION :: male 56 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 23,677,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 35 mg/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,1285,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 20,49,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9600 mg/kg

SEX/DURATION :: female 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 195,575,1977

Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S22-S26-S36/37/39
WGK Germany	2
RTECS	GD9095000

Precursor 8
141-82-2 123-08-0 1443678-33-8 60-18-4
540-38-5 79-10-7 106-41-2 74545-79-2
DownStream 10
107019-92-1 3943-97-3 3901-07-3 537-42-8
34071-95-9 501-98-4 501-36-0 61434-67-1
501-97-3 50463-48-4

7400-08-0	40458-57-9
57100-28-4	501-98-4
3943-97-3	150034-36-9
2631-82-5	614-60-8
3943-96-2	14755-02-3
1158522-08-7	940364-43-2
1219562-00-1	134104-43-1
131615-57-1	6906-52-1
930439-75-1	1018584-77-4
1114656-00-6	1218236-89-5