Tetramisole hydrochloride
Modify Date: 2024-01-02 10:18:21
Tetramisole hydrochloride structure
|
Common Name | Tetramisole hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 5086-74-8 | Molecular Weight | 240.752 | |
| Density | N/A | Boiling Point | 344.4ºC at 760 mmHg | |
| Molecular Formula | C11H13ClN2S | Melting Point | 266-267ºC | |
| MSDS | Chinese USA | Flash Point | 162.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Tetramisole hydrochlorideTetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. |
| Name | Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, hydrochloride (1:1) |
|---|---|
| Synonym | More Synonyms |
| Description | Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. |
|---|---|
| Related Catalog |
| Boiling Point | 344.4ºC at 760 mmHg |
|---|---|
| Melting Point | 266-267ºC |
| Molecular Formula | C11H13ClN2S |
| Molecular Weight | 240.752 |
| Flash Point | 162.1ºC |
| Exact Mass | 240.048798 |
| PSA | 40.90000 |
| LogP | 2.32160 |
| Water Solubility | 200 g/L (20 ºC) |
Synonym:DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride; (+-)-2,3,5,6-Tetrahycro-6-phenylimidazo (2,1-b)thiazole monohydrochloride; Tatramisole; DL-Tetramisole hydrochloride; Tetramisol hydrochlorid Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Harmful if swallowed.Toxic. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: Harmful if swallowed. The toxicological properties of this substance have not been fully investigated. Causes gastrointestinal tract irritation. Inhalation: The toxicological properties of this substance have not been fully investigated. Causes irritation of the mucous membrane and upper respiratory tract. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Wash area with soap and water. Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood. Storage: Keep containers tightly closed. Store in a cool, dry area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 5086-74-8: Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystals Color: white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 266.00 - 267.00 deg C Autoignition Temperature: 500 deg C ( 932.00 deg F) Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: 210 g/l (20C) Specific Gravity/Density: Not available. Molecular Formula: C11H12N2S.HCl Molecular Weight: 240.76 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, strong oxidants. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 5086-74-8: NJ5950000 LD50/LC50: CAS# 5086-74-8: Oral, mouse: LD50 = 210 mg/kg; Oral, rat: LD50 = 480 mg/kg. Oral, Human: TDLo=2 mg/kg Carcinogenicity: Tetramisole hydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. Safety Phrases: S 28B After contact with skin, wash immediately with plenty of water and soap. S 38 In case of insufficient ventilation, wear suitable respiratory equipment. WGK (Water Danger/Protection) CAS# 5086-74-8: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 5086-74-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 5086-74-8 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NJ5950000 |
| HS Code | 2934999090 |
|
~%
Tetramisole hyd... CAS#:5086-74-8 |
| Literature: American Cyanamid Company Patent: US4087611 A1, 1978 ; Title/Abstract Full Text Show Details American Cyanamid Company Patent: US4090025 A1, 1978 ; |
|
~%
Tetramisole hyd... CAS#:5086-74-8 |
| Literature: American Cyanamid Company Patent: US4090025 A1, 1978 ; |
|
~%
Tetramisole hyd... CAS#:5086-74-8 |
| Literature: DSO "Pharmachim" Patent: US4179460 A1, 1979 ; |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| HS Code | 2934100090 |
|---|---|
| Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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