Huwentoxin-IV

Modify Date: 2024-01-09 16:58:14

Huwentoxin-IV structure	Common Name	Huwentoxin-IV
	CAS Number	526224-73-7	Molecular Weight	4106.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇₄H₂₇₈N₅₂O₅₁S₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Huwentoxin-IV

Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain[1][2].

Name	Huwentoxin-IV

Description	Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	IC50: 26 nM (Nav1.7), 150 nM (Nav1.2), 338 nM (Nav1.3), 400 nM (Nav1.4)[1]
References	[1]. Xiao Y, et, al. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration. J Biol Chem. 2008 Oct 3;283(40):27300-13. [2]. Liu Y, et, al. Analgesic effects of Huwentoxin-IV on animal models of inflammatory and neuropathic pain. Protein Pept Lett. 2014; 21(2): 153-8.

Molecular Formula	C₁₇₄H₂₇₈N₅₂O₅₁S₆
Molecular Weight	4106.78

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Huwentoxin IV
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Huwentoxin-IV
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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