Rilmenidine

Modify Date: 2024-01-02 17:36:24

Rilmenidine Structure
Rilmenidine structure
Common Name Rilmenidine
CAS Number 54187-04-1 Molecular Weight 180.247
Density 1.5±0.1 g/cm3 Boiling Point 355.5±9.0 °C at 760 mmHg
Molecular Formula C10H16N2O Melting Point 106 - 107ºC
MSDS N/A Flash Point 168.8±18.7 °C

 Use of Rilmenidine


Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

 Names

Name N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
Synonym More Synonyms

 Rilmenidine Biological Activity

Description Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].
Related Catalog
In Vitro Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation[2]. Cell Viability Assay[2] Cell Line: K562 cells Concentration: 25, 50, 100 μM Incubation Time: 24 hours Result: Dose-dependently inhibited K562 colony formation.
In Vivo Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age[3].
References

[1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S.

[2]. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.

[3]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 355.5±9.0 °C at 760 mmHg
Melting Point 106 - 107ºC
Molecular Formula C10H16N2O
Molecular Weight 180.247
Flash Point 168.8±18.7 °C
Exact Mass 180.126266
PSA 33.62000
LogP 0.57
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.711
Storage condition Store at -20°C
Water Solubility H2O: 7.3 mg/mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP7207400
CHEMICAL NAME :
Oxazolidine, 2-((dicyclopropylmethyl)imino)-
CAS REGISTRY NUMBER :
54187-04-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H16-N2-O
MOLECULAR WEIGHT :
180.28
WISWESSER LINE NOTATION :
T5N CO AUTJ BMY- AL3TJ&- AL3TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 umol/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,527,1983

 Safety Information

Safety Phrases S22-S24/25
WGK Germany 3
RTECS RP7207400
HS Code 2934999090

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-Oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-
Rilmenidine
S 3341-3
S 3341
N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine
Oxaminozoline
hyperium
N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
2-[N-(Dicyclopropylmethyl)amino]oxazoline
EINECS 259-021-0
Tenaxum
MFCD00865924
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