Eriodictyol

Modify Date: 2024-01-02 12:49:49

Eriodictyol structure	Common Name	Eriodictyol
	CAS Number	552-58-9	Molecular Weight	288.252
	Density	1.6±0.1 g/cm3	Boiling Point	625.2±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₂O₆	Melting Point	270ºC
	MSDS	Chinese USA	Flash Point	241.9±25.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Eriodictyol

Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway.

Name	eriodictyol
Synonym	More Synonyms

Description	Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway.
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite
In Vitro	Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity[1]. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ25-35-induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons[2].
In Vivo	Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues[1].
Cell Assay	Primary cultures of cortical neurons are prepared from day 17 Sprague-Dawley rat embryos and maintained in Neurobasal A medium supplemented with B27. Experiments are performed 7 days after seeding. Aβ25-35 is dissolved in deionized distilled water at a concentration of 1 mM and incubated at 37°C for 7 days to induce its aggregation. Eriodictyol is added at indicated concentrations (20, 40, 80 μM) 2 h prior to Aβ25-35 treatment. Eriodictyol is dissolved in dimethyl sulfoxide (DMSO) at 64 mM as stock solution and diluted in culture medium before use[2].
Animal Admin	Mice[1] Eighty female C57BL/6 mice are anesthetized by an intraperitoneal injection of 150 mg/kg ketamine HCl and 65 µg/kg xylazine hydrochloride. E. coli LPS is instilled intratracheally (25 µg in 50 µL sterile saline) during inspiration. The control mice receive PBS instillation, while the Eriodictyol- and vehicle-treated mice receive Eriodictyol (30 mg/kg, dissolved in PBS) and vehicle (PBS), respectively, orally 2 days prior to the induction of ALI. The mice are then sacrificed by an intravenous injection of thiopental 24 h after the induction of ALI. The thorax is opened and the blood is sampled by cardiac puncture. Simultaneously, three bronchoalveolar lavage (BAL) procedures are performed, each using 0.5 mL normal saline. The blood is centrifuged (2,000 × g, for 10 min at 4°C) and the serum is stored for further processing; the survival curve is then depicted using the Kaplan-Meier method[1].
References	[1]. Zhu GF, et al. Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity. Exp Ther Med. 2015 Dec;10(6):2259-2266. Epub 2015 Oct 23. [2]. Jing X, et al. Eriodictyol Attenuates β-Amyloid 25-35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2. Neurochem Res. 2015 Jul;40(7):1463-71.

Density	1.6±0.1 g/cm3
Boiling Point	625.2±55.0 °C at 760 mmHg
Melting Point	270ºC
Molecular Formula	C₁₅H₁₂O₆
Molecular Weight	288.252
Flash Point	241.9±25.0 °C
Exact Mass	288.063385
PSA	107.22000
LogP	2.59
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.725
Storage condition	?20°C

Eriodictyol MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932999099

Precursor 3
CAS#:446-71-9 HOMOERIODICTYOL CAS#:480-18-2 Taxifolin CAS#:480-41-1 Naringenin
DownStream 3
CAS#:491-70-3 Luteolin CAS#:480-23-9 Orobol CAS#:57765-66-9 eriodictyol dih...

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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MFCD00135890

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EINECS 209-016-4

T66 BO EVT&J CR CQ DQ& GQ IQ &&S Form

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Eriodictyol

BioBioPha
China
Product Name: Eriodictyol
Price: ￥Inquiry/20mg
Purity: 98.0%
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Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Eriodictyol
Price: ￥788.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Eriodictyol
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Eriodictyol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: ERIODICTYOL
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥3960/10 mM * 1 mL in DMSO

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Eriodictyol

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