Maytansinol
Maytansinol structure
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Common Name | Maytansinol | ||
|---|---|---|---|---|
| CAS Number | 57103-68-1 | Molecular Weight | 565.055 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 835.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C28H37ClN2O8 | Melting Point | >153C (dec.) | |
| MSDS | N/A | Flash Point | 459.3±34.3 °C | |
Use of MaytansinolMaytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug. |
| Name | maytansinol |
|---|---|
| Synonym | More Synonyms |
| Description | Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 835.8±65.0 °C at 760 mmHg |
| Melting Point | >153C (dec.) |
| Molecular Formula | C28H37ClN2O8 |
| Molecular Weight | 565.055 |
| Flash Point | 459.3±34.3 °C |
| Exact Mass | 564.223816 |
| PSA | 130.09000 |
| LogP | 3.73 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.607 |
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Maytansinol CAS#:57103-68-1 |
| Literature: Journal of medicinal chemistry, , vol. 21, # 1 p. 31 - 37 |
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Maytansinol CAS#:57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
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Maytansinol CAS#:57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
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Maytansinol CAS#:57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
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Maytansinol CAS#:57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
|
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Maytansinol CAS#:57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
|
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Maytansinol CAS#:57103-68-1 |
| Literature: Tetrahedron, , vol. 35, p. 1079 - 1085 |
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Maytansinol CAS#:57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
![(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-9-hydroxy-5,12-dimethoxy-2,6,8,16-tetramethylspiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-3-one structure](https://image.chemsrc.com/caspic/363/75340-66-8.png)
![(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-5,12-dimethoxy-2,6,8,16-tetramethyl-3-oxospiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-9-yl carbamate structure](https://image.chemsrc.com/caspic/143/75349-68-7.png)
| Precursor 7 | |
|---|---|
| DownStream 3 | |
CAS#:139504-50-0
CAS#:66547-09-9| 4,24-Dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10,12,14(26),16,18-pentaene-8,23-dione, 11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-, (1S,2R,3S,5S,6S,16E,18E,20R,21S) 
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| Ansamitocin P0 |
| O3-de-(N-acetyl-N-methyl-L-alanyl)-maytansine |
| (3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84,12c-dihydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione |
| (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaene-8,23-dione |
| Maytansinol (7) |