57103-68-1
57103-68-1 structure
- Name: Maytansinol
- Chemical Name: maytansinol
- CAS Number: 57103-68-1
- Molecular Formula: C28H37ClN2O8
- Molecular Weight: 565.055
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
- Create Date: 2018-03-17 08:00:00
- Modify Date: 2024-01-02 18:14:21
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Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.
| Name | maytansinol |
|---|---|
| Synonyms |
4,24-Dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10,12,14(26),16,18-pentaene-8,23-dione, 11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-, (1S,2R,3S,5S,6S,16E,18E,20R,21S) 
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Ansamitocin P0 O3-de-(N-acetyl-N-methyl-L-alanyl)-maytansine (3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84,12c-dihydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaene-8,23-dione Maytansinol (7) |
| Description | Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 835.8±65.0 °C at 760 mmHg |
| Melting Point | >153C (dec.) |
| Molecular Formula | C28H37ClN2O8 |
| Molecular Weight | 565.055 |
| Flash Point | 459.3±34.3 °C |
| Exact Mass | 564.223816 |
| PSA | 130.09000 |
| LogP | 3.73 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.607 |
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57103-68-1 |
| Literature: Journal of medicinal chemistry, , vol. 21, # 1 p. 31 - 37 |
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57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
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57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
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57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
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57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
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57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
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57103-68-1 |
| Literature: Tetrahedron, , vol. 35, p. 1079 - 1085 |
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57103-68-1 |
| Literature: Journal of the American Chemical Society, , vol. 102, # 21 p. 6613 - 6615 |
| Precursor 7 | |
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| DownStream 3 | |
