139504-50-0
139504-50-0 structure
- Name: Mertansine
- Chemical Name: Mertansine
- CAS Number: 139504-50-0
- Molecular Formula: C35H48ClN3O10S
- Molecular Weight: 738.288
- Catalog: Signaling Pathways Antibody-drug Conjugate Drug-Linker Conjugates for ADC
- Create Date: 2018-07-12 13:46:54
- Modify Date: 2024-01-02 14:08:44
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Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.
| Name | Mertansine |
|---|---|
| Synonyms |
UNII-DDZ29HGH0E
DM1 Compound DM1 [Maytansinoid] (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2 S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate (non-preferred name) Maytansine,N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl) DM 1 Mertansine maytansinoid DM1 N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine maytansinoid DM 1 N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine |
| Description | Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. |
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| Related Catalog | |
| References |
| Density | 1.33±0.1 g/cm3 |
|---|---|
| Boiling Point | 937.1±65.0 °C at 760 mmHg |
| Melting Point | 190-192 ºC |
| Molecular Formula | C35H48ClN3O10S |
| Molecular Weight | 738.288 |
| Flash Point | 520.5±34.3 °C |
| Exact Mass | 737.274902 |
| PSA | 198.76000 |
| LogP | 4.76 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.599 |
| Storage condition | -20℃ |
| Water Solubility | Insuluble (2.4E-4 g/L) (25 ºC) |
|
~75%
139504-50-0 |
| Literature: Widdison, Wayne C.; Wilhelm, Sharon D.; Cavanagh, Emily E.; Whiteman, Kathleen R.; Leece, Barbara A.; Kovtun, Yelena; Goldmacher, Victor S.; Xie, Hongsheng; Steeves, Rita M.; Lutz, Robert J.; Zhao, Robert; Wang, Lintao; Blaettler, Walter A.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4392 - 4408 |
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~%
139504-50-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4392 - 4408 |
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~%
139504-50-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4392 - 4408 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |