400010-39-1
400010-39-1 structure
- Name: Cantuzumab mertansine
- Chemical Name: Cantuzumab mertansine
- CAS Number: 400010-39-1
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2023-01-11 16:40:16
- Modify Date: 2024-01-02 23:34:08
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Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].
| Name | Cantuzumab mertansine |
|---|
| Description | Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2]. |
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| Related Catalog | |
| In Vitro | Cantuzumab mertansine (SB-408075; huC242-DM1; 0-100 μM; 24 h) has selective cytotoxic activity on antigen-positive COLO 205 cell line[1]. Cell Cytotoxicity Assay[1] Cell Line: Antigen-positive COLO 205 cell line and the antigen-negative A-375 melanoma cell line Concentration: 0-100 μM Incubation Time: 24 h Result: Had cytotoxic activity on COLO 205 cells with an IC50 value of 0.032 nM (23.5 pg/ml). Had 1100-fold less cytotoxic activity for the antigen-negative A-375 cells (IC50=36 nM; 26.5 ng/ml). |
| In Vivo | Cantuzumab mertansine (SB-408075; huC242-DM1; 300 μg/kg/day for 5 days) resultes in complete regressions and cures of mice bearing human xenografts of Colo 205 colon cancer[1]. Animal Model: Female CB-17 SCID mice, 6-7 weeks of age bearing COLO 205 human colon tumor xenografts[1] Dosage: 300 μg/kg Administration: Daily for 5 days Result: Completely eliminated any measurable tumors within 2 weeks of the initiation of therapy, and all eight animals were tumor-free for 200 days (duration of the experiment). |
| References |
| No Any Chemical & Physical Properties |