N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE

Modify Date: 2024-01-08 13:49:53

N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE structure	Common Name	N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
	CAS Number	57159-62-3	Molecular Weight	307.09800
	Density	1.69 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₁BrN₂O₅	Melting Point	93-94ºC
	MSDS	N/A	Flash Point	N/A

Use of N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	N-Succinimidyl 3-(Bromoacetamido)propionate
Synonym	More Synonyms

Description	N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Density	1.69 g/cm3
Melting Point	93-94ºC
Molecular Formula	C₉H₁₁BrN₂O₅
Molecular Weight	307.09800
Exact Mass	305.98500
PSA	92.78000
Index of Refraction	1.566

Hazard Codes	Xi
HS Code	2925190090

N-Hydroxysuccinimide

CAS#:6066-82-6

N-Bromoacetyl-β...

CAS#:89520-11-6

~50%

N-SUCCINIMIDYL ...

CAS#:57159-62-3

Literature: Zaitsu; Ohnishi; Hosoya; Sugimoto; Ohkura Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1991 - 1997

Precursor 2
CAS#:6066-82-6 N-Hydroxysuccinimide CAS#:89520-11-6 N-Bromoacetyl-β...
DownStream 0

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%