SPDP structure
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Common Name | SPDP | ||
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CAS Number | 68181-17-9 | Molecular Weight | 312.365 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 465.9±55.0 °C at 760 mmHg | |
Molecular Formula | C12H12N2O4S2 | Melting Point | 84-86 °C(lit.) | |
MSDS | Chinese USA | Flash Point | 235.6±31.5 °C |
Use of SPDPSPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP . |
Name | N-Succinimidyl 3-(2-Pyridyldithio)propionate |
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Synonym | More Synonyms |
Description | SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP . |
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Related Catalog | |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 465.9±55.0 °C at 760 mmHg |
Melting Point | 84-86 °C(lit.) |
Molecular Formula | C12H12N2O4S2 |
Molecular Weight | 312.365 |
Flash Point | 235.6±31.5 °C |
Exact Mass | 312.023834 |
PSA | 127.17000 |
LogP | 0.99 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.650 |
Storage condition | −20°C |
Water Solubility | acetone: 50 mg/mL |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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Hazard Codes | Xi: Irritant; |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
~79% SPDP CAS#:68181-17-9 |
Literature: Shval'e, A. F.; Ofitserov, V. I.; Samukov, V. V. J. Gen. Chem. USSR (Engl. Transl.), 1985 , vol. 55, # 9 p. 2152,1909 - 1910 |
~74% SPDP CAS#:68181-17-9 |
Literature: Loccufier, J.; Schacht, E. Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 7 p. 535 - 540 |
~% SPDP CAS#:68181-17-9 |
Literature: Journal of the American Chemical Society, , vol. 129, # 31 p. 9640 - 9649 |
~%
Detail
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Literature: US4149003 A1, ; |
~% SPDP CAS#:68181-17-9 |
Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 55, # 9 p. 2152,1909 - 1910 |
~% SPDP CAS#:68181-17-9 |
Literature: Bulletin des Societes Chimiques Belges, , vol. 97, # 7 p. 535 - 540 |
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MFCD00009636 |
1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione |
EINECS 269-034-3 |
N-succinimidyl 3-(2-pyridyldithio)-propionate |
(2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate |
1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione |
2,5-Pyrrolidinedione, 1-[1-oxo-3-(2-pyridinyldithio)propoxy]- |
1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione |
2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)- |
SPDP |