Nomegestrol
Modify Date: 2024-01-06 11:05:21
Nomegestrol structure
|
Common Name | Nomegestrol | ||
|---|---|---|---|---|
| CAS Number | 58691-88-6 | Molecular Weight | 328.45 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 502.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H28O3 | Melting Point | 204-205ºC | |
| MSDS | N/A | Flash Point | 271.8±26.6 °C | |
Use of NomegestrolNomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity. |
| Name | 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity. |
|---|---|
| Related Catalog | |
| Target |
Kd: 5.44 nM (Rat uterine progesterone receptor)[1] |
| In Vitro | Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a Kd of 5.44 nM for rat uterine progesterone receptor[1]. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 502.6±50.0 °C at 760 mmHg |
| Melting Point | 204-205ºC |
| Molecular Formula | C21H28O3 |
| Molecular Weight | 328.45 |
| Flash Point | 271.8±26.6 °C |
| Exact Mass | 328.203857 |
| PSA | 54.37000 |
| LogP | 2.58 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.574 |
| Storage condition | 2~8°C |
| Risk Phrases | 63-50 |
|---|---|
| WGK Germany | 3.0 |
| Nomegestrol |
| (17a)-17-Acetyl-17-hydroxy-6-methylestra-4,6-dien-3-one |
| 19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- |
| Estra-4,6-dien-3-one, 17-acetyl-17-hydroxy-6-methyl-, (17α)- |
| 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione |