58691-88-6

58691-88-6 structure

Name: Nomegestrol
Chemical Name: 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
CAS Number: 58691-88-6
Molecular Formula: C₂₁H₂₈O₃
Molecular Weight: 328.45
Catalog: API Hormone and endocrine-regulating drugs Estrogen and progestogen drugs
Create Date: 2018-05-21 08:00:00
Modify Date: 2024-01-06 11:05:21
Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

Name	17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
Synonyms	Nomegestrol (17a)-17-Acetyl-17-hydroxy-6-methylestra-4,6-dien-3-one 19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- Estra-4,6-dien-3-one, 17-acetyl-17-hydroxy-6-methyl-, (17α)- 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione

Description	Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Others
Target	Kd: 5.44 nM (Rat uterine progesterone receptor)[1]
In Vitro	Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a Kd of 5.44 nM for rat uterine progesterone receptor[1]. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity[2].
References	[1]. Duc I, et al. Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus. Steroids. 1991 Jun;56(6):325-8. [2]. Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76(6):531-9.

Risk Phrases	63-50
WGK Germany	3.0