Bis-acrylate-PEG5

Modify Date: 2024-01-08 14:39:09

Bis-acrylate-PEG5 Structure
Bis-acrylate-PEG5 structure
Common Name Bis-acrylate-PEG5
CAS Number 59256-52-9 Molecular Weight 346.37300
Density 1.098g/cm3 Boiling Point 421.5ºC at 760 mmHg
Molecular Formula C16H26O8 Melting Point N/A
MSDS N/A Flash Point 181.9ºC

 Use of Bis-acrylate-PEG5


Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethoxy]ethoxy]ethyl prop-2-enoate
Synonym More Synonyms

 Bis-acrylate-PEG5 Biological Activity

Description Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.098g/cm3
Boiling Point 421.5ºC at 760 mmHg
Molecular Formula C16H26O8
Molecular Weight 346.37300
Flash Point 181.9ºC
Exact Mass 346.16300
PSA 89.52000
LogP 0.51120
Index of Refraction 1.458

 Synonyms

EINECS 261-677-8
16-oxo-3,6,9,12,15-pentaoxaoctadec-17-en-1-yl acrylate
3,6,9,12-Tetraoxatetradecane-1,14-diyl diacrylate
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