Bis-acrylate-PEG6

Modify Date: 2024-01-03 15:47:41

Bis-acrylate-PEG6 Structure
Bis-acrylate-PEG6 structure
Common Name Bis-acrylate-PEG6
CAS Number 85136-58-9 Molecular Weight 390.42500
Density 1.101g/cm3 Boiling Point 459.125ºC at 760 mmHg
Molecular Formula C18H30O9 Melting Point N/A
MSDS N/A Flash Point 196.816ºC

 Use of Bis-acrylate-PEG6


Bis-acrylate-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl prop-2-enoate
Synonym More Synonyms

 Bis-acrylate-PEG6 Biological Activity

Description Bis-acrylate-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.101g/cm3
Boiling Point 459.125ºC at 760 mmHg
Molecular Formula C18H30O9
Molecular Weight 390.42500
Flash Point 196.816ºC
Exact Mass 390.18900
PSA 98.75000
LogP 0.52780
Index of Refraction 1.46

 Safety Information

Hazard Codes Xi

 Synonyms

EINECS 285-782-3
2-Propenoic acid,1,1'-(3,6,9,12,15-pentaoxaheptadecane-1,17-diyl) ester
2-Propenoicacid,3,6,9,12,15-pentaoxaheptadecane-1,17-diyl ester (9CI)
Hexaethyleneglycoldiacrylate
3,6,9,12,15-Pentaoxaheptadecane-1,17-diyl diacrylate
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