NH-bis-PEG5

Modify Date: 2024-01-09 15:37:25

NH-bis-PEG5 Structure
NH-bis-PEG5 structure
Common Name NH-bis-PEG5
CAS Number 63721-06-2 Molecular Weight 457.55600
Density N/A Boiling Point N/A
Molecular Formula C20H43NO10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NH-bis-PEG5


NH-bis-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 NH-bis-PEG5 Biological Activity

Description NH-bis-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C20H43NO10
Molecular Weight 457.55600
Exact Mass 457.28900
PSA 126.33000

 Synonyms

3,6,9,12,18,21,24,27-Octaoxa-15-azanonacosane-1,29-diol