Thymine-beta-D-arabinofuranoside

Modify Date: 2024-01-05 08:54:12

Thymine-beta-D-arabinofuranoside structure	Common Name	Thymine-beta-D-arabinofuranoside
	CAS Number	605-23-2	Molecular Weight	258.23
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₄N₂O₆	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Thymine-beta-D-arabinofuranoside

Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-.β.-D-Arabinofuranosylthymine
Synonym	More Synonyms

Description	Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₀H₁₄N₂O₆
Molecular Weight	258.23
Exact Mass	258.085175
PSA	124.78000
LogP	-1.02
Index of Refraction	1.619
Storage condition	2-8°C

Thymine-beta-D-arabinofuranoside MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XP2100200

CHEMICAL NAME :: Thymine, 1-beta-D-arabinofuranosyl-

CAS REGISTRY NUMBER :: 605-23-2

BEILSTEIN REFERENCE NO. :: 0090166

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H14-N2-O6

MOLECULAR WEIGHT :: 258.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 7100 ug/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 23,141,1978

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	XP2100200

Precursor 9
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Thymine arabinofuranoside

Thymine, 1-β-D-arabinofuranosyl-

1-(β-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

spongothymidine

thymine arabinoside

ARABINOFURANOSYL-5-METHYLURACIL

EINECS 210-083-7

MFCD00065474

1-(β-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione

1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidindion

5-Methyl-1-pentofuranosyl-2,4(1H,3H)-pyrimidinedione

ARA-T

5-Methyl-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione

2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-5-methyl-

1-[3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-5-méthyl-2,4(1H,3H)-pyrimidinedione

2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-pentofuranosyl-

1-B-D-Arabinofuranosylthymine

spongothymidin

Arabinofuranosylthymine

1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Thymine 1-beta-D-arabinofuranoside

1-β-D-Arabinofuranosylthymine

arabinosylthymine

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Thymine-beta-D-arabinofuranoside
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Thymine-beta-D-arabinofuranoside
Price: ￥3858.0/50mg
Purity: 99.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Thymine-beta-D-arabinofuranoside
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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