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605-23-2

605-23-2 structure
605-23-2 structure
  • Name: Thymine-beta-D-arabinofuranoside
  • Chemical Name: 1-.β.-D-Arabinofuranosylthymine
  • CAS Number: 605-23-2
  • Molecular Formula: C10H14N2O6
  • Molecular Weight: 258.23
  • Catalog: Biochemical Carbohydrate Monosaccharide
  • Create Date: 2018-12-31 12:59:14
  • Modify Date: 2024-01-05 08:54:12
  • Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name 1-.β.-D-Arabinofuranosylthymine
Synonyms Thymine arabinofuranoside
Thymine, 1-β-D-arabinofuranosyl-
1-(β-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
spongothymidine
thymine arabinoside
ARABINOFURANOSYL-5-METHYLURACIL
EINECS 210-083-7
MFCD00065474
1-(β-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidindion
5-Methyl-1-pentofuranosyl-2,4(1H,3H)-pyrimidinedione
ARA-T
5-Methyl-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-5-methyl-
1-[3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-5-méthyl-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-pentofuranosyl-
1-B-D-Arabinofuranosylthymine
spongothymidin
Arabinofuranosylthymine
1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Thymine 1-beta-D-arabinofuranoside
1-β-D-Arabinofuranosylthymine
arabinosylthymine
Description Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Density 1.6±0.1 g/cm3
Molecular Formula C10H14N2O6
Molecular Weight 258.23
Exact Mass 258.085175
PSA 124.78000
LogP -1.02
Index of Refraction 1.619
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XP2100200
CHEMICAL NAME :
Thymine, 1-beta-D-arabinofuranosyl-
CAS REGISTRY NUMBER :
605-23-2
BEILSTEIN REFERENCE NO. :
0090166
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C10-H14-N2-O6
MOLECULAR WEIGHT :
258.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
7100 ug/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 23,141,1978
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS XP2100200